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Ziyin Ye

As seen in: Nature
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Articles by Ziyin Ye

MUC1 attenuates chronic obstructive pulmonary disease through integrated regulation of pulmonary epithelial cell senescence, transdifferentiation, and inflammatory cascades

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By Zili Zhang, Defu Li, Weiguo Kong, Fei Liu, Fanjie Lin, Lulu Wu, Jiayu Zhuang, lixia He, Yuanyuan Li, Lingdan Chen, Xiaochang Wang, Yuhan Jiang, Fang Tian, Ting Lu, Jingyi Xu, Hongwei Yao, Tao Wang, Zeguang Zheng, Dejun Sun, Jian Wang, Nanshan Zhong, Wenju Lu, Zeqiang Lin, Yuanfang Xie, Qiaojian Zhong, Ziyin Ye, Kwang Chul Kim
| Nature Verified
Abstract Impaired pulmonary epithelial cell homeostasis is a key pathogenic feature in chronic obstructive pulmonary disease (COPD). Mucin 1 (MUC1/Muc1) is a membrane-tethered glycoprotein that plays important roles in modulating various disease progression. This study aims to decipher the role and mechanisms of MUC1 in the pathogenesis of COPD. We found functional variants (rs4072037 T > C and rs12411216 C > A) in MUC1 were associated with increased susceptibility to COPD.
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