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MUC1 attenuates chronic obstructive pulmonary disease through integrated regulation of pulmonary epithelial cell senescence, transdifferentiation, and inflammatory cascades
Abstract Impaired pulmonary epithelial cell homeostasis is a key pathogenic feature in chronic obstructive pulmonary disease (COPD). Mucin 1 (MUC1/Muc1) is a membrane-tethered glycoprotein that plays important roles in modulating various disease progression. This study aims to decipher the role and mechanisms of MUC1 in the pathogenesis of COPD. We found functional variants (rs4072037 T > C and rs12411216 C > A) in MUC1 were associated with increased susceptibility to COPD.
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