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RNA-seq analysis revealed genes associated with neuropathic pain induced by chronic compressive injury in interferon regulatory factors 4 knockout mice - Jiayi Peng, Yunlin Wu, Qi E, Ziyin Zhou, Xianjie Wen, 2023
Introduction Neuropathic pain is a type of chronic pain characterized by spontaneous pain, hyperalgesia, abnormal pain, and paresthesia.1,2 Its etiology includes physical mechanical injury, metabolic or nutritional neurological changes, viral infection, neurotoxicity of drugs or radiotherapy, ischemic neurological damage, neurotransmitter dysfunction, etc.3–8 Owing to the increased expression of Na+ channels and voltage-gated Ca2+ channels in the cell membrane of injured neurons, abnormal...
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