Ziying Wang
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Plant-specific and conserved mechanisms of the polymerase-associated factor 1 complex in replication stress responses
Abstract DNA replication stress threatens genome stability, but how plants respond to this challenge remains unclear. Here we show that the evolutionarily conserved polymerase-associated factor 1 complex (PAF1C) is required for the replication stress response in Arabidopsis. Plants lacking functional PAF1C are hypersensitive to replication stress-inducing agents.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism
Main text (Cell Metabolism 32, 1052–1062.e1–e8; December 1, 2020) In the original version of this article, the authors inadvertently misused the representative immunofluorescence image of WT-1 (green) for the Cre+/Jaml+/+ control group (left panel) in Figure 2E during the figure compilation. This error does not affect the results or conclusions of the paper. The authors sincerely apologize for any confusion that the oversight may have caused.
Inflammatory-neurological deficit versus metabolic dysregulation: unsupervised clustering and SHAP analysis
Abstract Objective: This retrospective cohort study enrolled 20,538 middle-aged and older patients with acute ischemic stroke (AIS) to identify immune-metabolic clinical subtypes by unsupervised clustering, to examine the differential association between subtype characteristics and post-stroke epilepsy (PSE) susceptibility, and to clarify immune-related threshold biomarkers for individualized PSE risk stratification.
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