Zsuzsanna Demeter on Muck Rack

Zsuzsanna Demeter

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Articles

Translational difficulties in establishing a pharmacologically induced neurovascular uncoupling model in rats

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By Bence Varga, Aliz Judit Ernyey, Brigitta Tekla Tajti, Attila Gaspar, Levente Kollár, Peter Kovacs, Alan Alpar, István Gyertyán, Zsuzsanna Demeter, Mihály Albert
| Nature Verified
Abstract Neurovascular uncoupling (NVU) contributes to neurological disorders like Alzheimer’s disease. While a mouse NVU model exists, a reliable rat model critical for cognitive research remains underdeveloped. To address this methodological gap, we investigated a pharmacological approach in rats using the same drugs (N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide (MS-PPOH), L-NG-nitroarginine methyl ester (L-NAME), indomethacin) that proved to be efficacious in mice.
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