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Zuyin Yu on Muck Rack

Zuyin Yu

As seen in: Nature
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Articles

1,2-propanediol ameliorated radiation-induced intestinal injury in mice

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By Jiwei Zhao, Chunan Zhao, Xing Shen, Ying Jiang, Aoqiang Ji, Xuewen Zhang, Shuang Xing, Gang Sun, He Xiao, Zuyin Yu
| Nature Verified
Abstract Radiotherapy is constricted by collateral normal tissue injury during treatment, particularly the gastrointestinal tracts, which is usually referred as radiation-induced gastrointestinal syndrome (RIGS). Currently, there is no FDA-approved agent for the prevention or treatment of RIGS. By using a mice model of RIGS, we demonstrated that 1,2-propanediol (1,2-PD) prevents radiation-induced fatal intestinal injury and significantly increases mice survival following lethal doses of radiation.
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