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Articles

A JAK/STAT-Pdk1-S6K axis bypasses systemic growth restrictions to promote regeneration - Nature Communications

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By Ananthakrishnan Vijayakumar Maya, aakriti singh, Lara E. Heckmann, Katrin Kierdorf, Jörg Büscher
| Nature Verified
Abstract Inflammation triggers systemic growth restrictions, a process well characterised in tumour cachexia. Whether inflammatory tissue damage also induces growth restrictions, and how regenerating tissue overcome them, is less explored. Using a tissue damage model in Drosophila, we identify metabolic and signaling adaptations that both induce and bypass systemic growth restrictions.
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Dissecting the enhancer gene regulatory network in early Drosophila spermatogenesis - Nature Communications

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By Kerem Yildirim, Tim Lange, Laura Zoe Kreplin, Qian Wang, Katrin Domsch, Anniek Stokkermans, aakriti singh, Josephine Bageritz, Pallavi Santhi Sekhar, Vigneshwarr Muruga Boopathy, Kim Dammer, Shubhanshu Pandey, Xuefan Gao
| Nature Verified
Abstract Cellular decision-making and tissue homeostasis are governed by transcriptional networks shaped by chromatin accessibility. Using single-nucleus multi-omics, we jointly profile gene expression and chromatin accessibility in 10,335 cells from the Drosophila testis apical tip. This enables inference of 147 cell type-specific enhancer-gene regulons using SCENIC + .
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A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia

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By Magnus Ölander, Daniel Vazquez, Karsten Meier, aakriti singh
| PLOS Biology Verified
Loading metrics Open Access Peer-reviewed Research Article Citation: Ölander M, Rea Vázquez D, Meier K, Singh A, Silva de Sousa A, Puértolas-Balint F, et al. (2025) A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia. PLoS Biol 23(4): e3003123. https://doi.org/10.1371/journal.pbio.3003123 Academic Editor: Tobias Bollenbach, Universität zu Köln, GERMANY Received: February 21, 2025; Accepted: March 19, 2025; Published: April 29, 2025 Copyright: © 2025 Ölander et al.
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