Aakrosh Ratan

ReportOnline now100580Open access Affiliations & Notes 1Department of Cell Biology, University of Virginia, Charlottesville, VA 22903 2Department of Biology, University of Virginia, Charlottesville, VA 22903 3Department of Genome Sciences, University of Virginia, Charlottesville, VA 22903 Article Info Publication History: Received October 14, 2025; Revised February 4, 2026; Accepted February 6, 2026; Published online February 10, 2026 DOI: 10.1016/j.xhgg.2026.100580 External LinkAlso...

Abstract Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, yet predicting patient response remains a major challenge. Carcinoma ecotypes, which capture the cancer-immune interactions, show promise as prognostic biomarkers but remain untested in real-world settings. We compile and analyze the ORIEN Avatar ICI cohort of 1610 patients with matched gene expression data from a broader dataset of 14,997 individuals.

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