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Aashi Inani on Muck Rack

Aashi Inani

As seen in: Nature
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Articles

De novo design of protein antagonists of bacterial pathogen type III secretion system needle assembly

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By Ruoqing Jia, Ji Yoon Jung, Evan N. Whitford, Hongwei Wu, Nicolas J. Pizzala, Vicki H. Wysocki, Ingeborg Schmidt-Krey, Andrew C. McShan, Aashi Inani, Monneh W. Diggs, Cara N. Dougan, Morgan A. Zitsch, Katherine J. Kenney
| Nature Verified
Abstract The type III secretion system (T3SS), a nanoinjector apparatus utilized by Gram-negative bacterial pathogens to colonize host cells, represents a promising target for antibiotic-independent therapeutics. To date, molecules identified to associate with T3SS components have been largely limited to natural proteins, small molecules, and antibodies. Here, we report the rational design and characterization of de novo proteins that associate with the T3SS needle protein.
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