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Ingeborg Schmidt-Krey on Muck Rack

Ingeborg Schmidt-Krey

As seen in: Nature
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Articles

De novo design of protein antagonists of bacterial pathogen type III secretion system needle assembly

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By Ruoqing Jia, Ji Yoon Jung, Evan N. Whitford, Hongwei Wu, Nicolas J. Pizzala, Vicki H. Wysocki, Ingeborg Schmidt-Krey, Andrew C. McShan, Aashi Inani, Monneh W. Diggs, Cara N. Dougan, Morgan A. Zitsch, Katherine J. Kenney
| Nature Verified
Abstract The type III secretion system (T3SS), a nanoinjector apparatus utilized by Gram-negative bacterial pathogens to colonize host cells, represents a promising target for antibiotic-independent therapeutics. To date, molecules identified to associate with T3SS components have been largely limited to natural proteins, small molecules, and antibodies. Here, we report the rational design and characterization of de novo proteins that associate with the T3SS needle protein.
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Complementary Mutations in the N and L Proteins for Restoration of Viral RNA Synthesis

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By Weike Li, Ryan H. Gumpper, Yusuf Uddin, Ingeborg Schmidt-Krey
| asm.org
ABSTRACTDuring viral RNA synthesis by the viral RNA-dependent RNA polymerase (vRdRp) of vesicular stomatitis virus, the sequestered RNA genome must be released from the nucleocapsid in order to serve as the template. Unveiling the sequestered RNA by interactions of vRdRp proteins, the large subunit (L) and the phosphoprotein (P), with the nucleocapsid protein (N) must not disrupt the nucleocapsid assembly.
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