Aasta Gandhi

Abstract Hypotension is an under-recognized consequence of spinal cord injury (SCI). Clinical assessments, such as head-up tilt testing, are resource-intensive and carry safety risks. In this study, we evaluated the validity of the hypotension symptom domain of the Autonomic Dysfunction Following Spinal Cord Injury (ADFSCI) questionnaire as a patient-reported outcome measure for hypotension-related symptoms in individuals with SCI.

Abstract A spinal cord injury (SCI) causes immediate and sustained hemodynamic instability that threatens neurological recovery and impacts quality of life. Here we establish the clinical burden of chronic hypotensive complications due to SCI in 1,479 participants and expose the ineffective treatment of these complications with conservative measures.

The authors declare competing financial interests: G.C., A.Phillips., J.W.S, J.Bloch., R.D., L.Asboth, T.M. and A.R. hold various patents in relation with the present work. G.C., A.Philips., J.Bloch, V.D., J.Murphy and H.L. are minority shareholders of ONWARD medical, a company with direct relationships with the presented work. G.C., J.Bloch., A.Phillips. and R.D. are consultants of ONWARD medical.