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Aavash Baral

As seen in: Nature, DEV Community
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Articles

Aurora kinase A is a synthetic lethal target in FANCA-deficient cancers

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By Dilara Akhoundova, Martín González-Fernández, Aavash Baral, Andrej Benjak, Carmen Perry, Saskia Hussung, Sina Maletti, Aino Paasinen-Sohns, Marika Lehner, Bastian Dislich, Erik Vassella, Simone de Brot, Carmen Cardozo, Ralph Fritsch, Clelia Pistoni, Seynabou Diop, Phillip Thienger, Muriel Jaquet, Smruthy Sivakumar, David E. Root, Paola Francica, Sven Rottenberg, Mark A. Rubin, Ladina Hörtensteiner, Lea Lingg, Therese Waldburger, Petros Tsiridis, Taina Kaiponen, Mariana Ricca, Christopher McDermott-Roe
| Nature Verified
Abstract Loss-of-function genomic alterations in FANCA occur across multiple cancer types, yet no molecularly tailored therapies have successfully exploited this potential vulnerability. Using complementary unbiased approaches, including a genome-wide CRISPR/Cas9 loss-of-function screen and a high-throughput drug screen in isogenic cancer cell-based models, we identified Aurora kinase A (AURKA) as a reproducible synthetic lethal target of FANCA-deficient cancers.
Open in Who Shared Issue with article?

I Built an Offline-First Semantic Search Engine in JavaScript

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By Aavash Baral
| DEV Community
Search is deceptively hard. Most JavaScript search libraries stop at keywords or fuzzy matching, and most semantic search solutions assume external APIs, vector databases, or hosted services. I wanted something different: runs fully locally works in Node.js or the browser understands meaning, not just text doesn’t require standing up new infrastructure That led me to build Simile Search — an offline-first semantic + fuzzy search engine in JavaScript.
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