Abhilash Barpanda

Keywords autophagy lysosome MHC-I ER-phagy pancreatic cancer Introduction Autophagy is an evolutionarily conserved self-recycling pathway that cancer cells co-opt to maintain metabolic fitness, increase stress adaptation, and decrease their immunogenicity.1,2 Autophagy is critical for the growth of highly aggressive pancreatic ductal adenocarcinoma (PDAC) cells and tumors.3,4 Through both transcriptional and post-transcriptional mechanisms, PDAC cells upregulate the biogenesis of both...

Abstract Pulmonary veno-occlusive disease (PVOD) is a rare and severe subtype of pulmonary arterial hypertension, marked by progressive remodeling of small pulmonary arteries and veins with no therapies. Using a mitomycin C (MMC)-induced rat model, we previously demonstrated that protein kinase R (PKR)-mediated integrated stress response (ISR) drives endothelial dysfunction and vascular remodeling.

1. Introduction Meningioma, the most common primary intracranial tumor, is predominantly slow-growing and known to arise primarily from arachnoid cap cells [1]. Meningioma has broadly been classified into 3 grades, majorly relying on histopathology and cytomorphological criteria. Grade I (benign) tumors comprise 95% of total meningioma cases, grade II (atypical) tumors comprise 4–5%, and, grade III (anaplastic) tumors comprising less than 1% are fast-growing malignant tumors [2].