Abhishek Sharma

Join the DZone community and get the full member experience. Join For Free For years, service organizations measured operational efficiency through response time. A machine failed, a ticket dropped, a technician arrived on-site, and the diagnosis and repair resolved the issue. Industries dependent on physical assets accepted this framework because they believed that it was not possible to avoid downtime.

Abstract Inhibition of PARPs is a key strategy to treat tumours with defects in homologous recombination (HR), including those with mutations in the tumour suppressor gene BRCA2. PARP inhibitors generate replication stress, creating a dependence on HR to repair the resulting DNA damage. However, the DNA lesions generated upon PARP inhibition that impede replication fork progression and trigger a requirement for BRCA2 in cell survival are poorly defined.

Abstract Expansive soils pose significant challenges to construction of pavements because of their swelling behaviour, low strength and high moisture sensitivity. This paper examines the use of cement kiln dust (CKD) and polypropylene fiber (PPF) as chemical and mechanical stabilizers respectively to enhance expansive subgrade soil and assesses the implication of this on the thickness of flexible pavement based on the IRC guidelines.