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Abraham L. Brass

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Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

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By George Savidis, Paul Meraner, Jill M. Perreira, Jocelyn M. Portmann, Nicholas Renzette, Zhiru Guo, William M. McDougall, Gaia Trincucci, Sinu P. John, Aaron M. Aker, Douglas R. Robbins, Sharone Green, Timothy F. Kowalik, Abraham L. Brass
| Cell Press Verified
EMC Is Required for the Replication of ZIKV, DENV, and YFV   A Role for the EMC in Early DENV and ZIKV Replication   The EMC Associates with the OST Complex   The Role of AXL in Flavivirus Replication   The Role of the EMC in Flavivirus Infection We developed an RNAi screening platform for DENV-HFs (Figures 1Figures 1A and 1B ). After 72 hr of siRNA transfection, HeLa cells were infected with DENV serotype 2-New Guinea C strain (DENV2-NGC, MOI 0.5; Figure 1Figure 1A).
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