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Articles by Ada Yonath
A small nucleolar RNA dictates the structure and function of translating ribosomes in Leishmania
Abstract The most common rRNA modification is 2’-O-methylation. Here, we determine the landscape of 2’-O-methylation in Leishmania, a parasite that cycles between two different hosts, insect and mammalian. We find two 2’-O-methylated positions that are differentially modified during the parasite’s two life stages.
Structural and molecular basis of specialized translation mediated by the ribosome mRNA-binding channel
Abstract The ribosome mRNA channel is central to translation, yet its role in regulatory mechanisms remains unclear. Using cryo-EM of human ribosomal complexes bound to Kozak and TISU mRNAs from wild-type (WT) and RPS26/eS26 mutant (RPS26dC) cells, we demonstrate that both RPS26/eS26 and mRNA adopt distinct conformations, explaining the opposing effects of RPS26dC on their activity.
Systematic Exploration of Functional Group Relevance for Anti-Leishmanial Activity of Anisomycin
Open AccessArticle by 1,*, 2, 3,4, Ana Victoria Ibarra-Meneses 3,4, 2, 2, 5, 6,7, Christopher Fernandez-Prada 3,4 and 1,* 1 Department of Chemistry, Université de Montréal, Montreal, QC H3T 1J4, Canada 2 Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel 3 Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada 4 The Research Group on Infectious Diseases in...
Transform
Transform is an online platform for conversations about how technology affects our world. Published several times a year, it looks at how tech is shaping the present, and provides a glimpse of the future.
Ada E. Yonath: “The challenge of science is like climbing Mount Everest”
Israeli crystallographer Ada E. Yonath, a 2008 laureate of the L’Oreal-UNESCO For Women in Science Awards, went on to win the Nobel Prize in Chemistry in 2009 for her pioneering discoveries on the structure and function of ribosomes, the protein synthesizers in cells. Her research has also been key to understanding how antibiotics work.
Hibernating Bears, Antibiotics, and the Evolving Ribosome (Nobel Lecture)
High‐resolution structures of ribosomes, the cellular machines that translate the genetic code into proteins, revealed the decoding mechanism, detected the mRNA path, identified the sites of the tRNA molecules in the ribosome, elucidated the position and the nature of the nascent proteins exit tunnel, illuminated the interactions of the ribosome with non‐ribosomal factors, such as the initiation, release and recycling factors.
Hibernating Bears, Antibiotics, and the Evolving Ribosome (Nobel Lecture)
High‐resolution structures of ribosomes, the cellular machines that translate the genetic code into proteins, revealed the decoding mechanism, detected the mRNA path, identified the sites of the tRNA molecules in the ribosome, elucidated the position and the nature of the nascent proteins exit tunnel, illuminated the interactions of the ribosome with non‐ribosomal factors, such as the initiation, release and recycling factors.
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