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Adam W. Barb on Muck Rack

Adam W. Barb

As seen in: Wiley Online Library, BioRxiv, eLife, The Journal of Biological Chemistry
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Articles

One N-glycan regulates natural killer cell antibody-dependent cell-mediated cytotoxicity and modulates Fc γ receptor IIIa/CD16a structure

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By Paul Kremer, Elizabeth A Lampros, Allison M Blocker, Adam W. Barb
| eLife
eLife Assessment This study explores the mechanistic link between glycosylation at the N162 site of the Fc gamma receptor FcγRIIIa and the modulation of NK cell-mediated antibody-dependent cytotoxicity. Using innovative isotope labeling strategies and advanced NMR spectroscopy techniques, the authors provide compelling evidence of how glycan composition influences receptor stability and immune function.
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One N-glycan regulates natural killer cell antibody-dependent cell-mediated cytotoxicity and modulates Fc γ receptor IIIa / CD16a structure

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By Paul Kremer, Adam W. Barb, Elizabeth A Lampros, Allison M Blocker
| BioRxiv
Abstract Both endogenous antibodies and a subset of antibody therapeutics engage Fc gamma receptor (FcγR)IIIa / CD16a to stimulate a protective immune response. Increasing the FcγRIIIa/IgG1 interaction improves the immune response and thus represents a strategy to improve therapeutic efficacy. FcγRIIIa is a heavily glycosylated receptor and glycan composition affects antibody-binding affinity.
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Inhibiting N‐glycan processing increases the antibody binding affinity and effector function of human natural killer cells

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By Harrison Hughes, Paul Kremer, Ganesh P Subedi, Adam W. Barb
| Wiley Online Library Verified
Abstract Novel approaches are required to improve the efficacy of immunotherapies and increase the proportion of patients who experience a benefit. Antibody-dependent cell-mediated cytotoxicity (ADCC) contributes to the efficacy of many monoclonal antibodies therapies. Natural killer (NK) cells mediate ADCC, though responses are highly variable and depend on prior treatment as well as other factors. Thus, strategies to increase NK cell activity are expected to improve multiple therapies.
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