Adele Mitchell

Keywords SOD1 superoxide dismutase ALS amyotrophic lateral sclerosis Lou Gehrig disease MAVE multiplexed assay of variant effect variant-effect mapping deep mutational scanning variant classification Introduction Amyotrophic lateral sclerosis (ALS; MIM: 105400) is a heritable mainly autosomal-dominant neurodegenerative disease with a lifetime prevalence of 1 per 300 people.1,2,3 SOD1 encodes the ubiquitously expressed free-radical-scavenging enzyme Cu2+/Zn2+ superoxide dismutase 1 (MIM:...

From enduro mountain bikers to cycling commuters, competitive racers to those who pootle round the park, women cycle for fitness, fun, practicality and adventure. But what happens if menopausal symptoms start to disrupt your enjoyment of cycling or hinder your performance? Conversely, can cycling actually help combat those symptoms? Menopause impacts each woman differently: some barely notice it, while others are floored by it.

Our Inspiring Women interviews have featured a wide range of people from local heroes to seasoned pros. Whatever they are doing now they’ve all had an adventure sport background which makes it easy to see how they’ve ended up mountain biking. Adele Mitchell – from teenage girls’ fashion to mountain biking Our very own contributor Adele Mitchell is a bit different.