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Eyes of Africa: The Genetics of Blindness. Baseline characteristics, ocular features, and associations with glaucoma in continental Africans
Abstract Glaucoma is the leading cause of irreversible blindness worldwide, with disproportionately high prevalence and severity in Africans. To characterise the baseline phenotypic findings and glaucoma-related ocular features of participants with primary open-angle glaucoma (POAG, cases) and non-glaucoma controls and to report sociodemographic and medical associations of POAG in the cohort. Multicentre, cross-sectional study.
Multi-ancestry transcriptome-wide association studies uncover insights into breast cancer genetics and biology
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Abstract Genome-wide association studies (GWAS) have identified over 200 genetic risk loci for breast cancer, yet their target genes remain largely unknown. We conduct multi-ancestry transcriptome-wide association studies (TWAS) to discover potential breast cancer susceptibility genes.
By Jie Ping, Guochong Jia, Qiuyin Cai, Xingyi Guo, Jifeng Wang, Ran Tao, Bingshan Li, Joshua A. Bauer, Yuhan Xie, Stefan Ambs, Mollie E Barnard, Yu Chen, Ji-Yeob Choi, Yu-Tang Gao, Montserrat Garcia-Closas, Jian Gu, Jennifer Hu, Motoki Iwasaki, Esther M John, Sun-Seog Kweon, Christopher I Li, Koichi Matsuda, Keitaro Matsuo, Katherine L. Nathanson, Barbara Nemesure, Olufunmilayo I. Olopade, Tuya Pal, Sue K Park, Boyoung Park, Michael Press, Maureen Sanderson, Dale P. Sandler, Song T. Yao, Ying Zheng, Thomas Ahearn, Abenaa M. Brewster, Anselm Hennis, Hidemi Ito, Michiaki Kubo, Eun-Sook Lee, Katie O’Brien, Oladosu Ojengbede, Andrew F. Olshan, Min-Ho Park, Sonya Reid, Taiki Yamaji, Gary R. Zirpoli, Ebonee N. Butler, Maosheng Huang, Siew-Kee Low, John Oladapo Obafunwa, Clarice R. Weinberg, Haoyu Zhang, Hongyu Zhao, Christine B. Ambrosone, Michelle Cote, Dezheng Huo, Christopher A. Haiman, Daehee Kang, Julie Palmer, Melissa A. Troester, Xiao-Ou Shu, Jirong Long, Wei Zheng, Adeyinka Falusi, Timothy Makumbi, Berthe S. E. Mapoko, Dong-Young Noh
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Nature
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