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Aditee Kadam

As seen in: Cell Reports
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Articles

Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice

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By Jung-Seok Kim, Sébastien Trzebanski, Sun-Hye Shin, Lior Schori, Noa Chapal Ilani, Rocio Vicario, Oliver Aust, Polina Bugaeva, Christian Hoffmann, Marina Scheller, Sigalit Boura-Halfon, Nathali Kaushansky, Ofra Golani, Aryeh Solomon, Zhaoyuan Liu, Lukas Amann, Stefan Koch, Nikolaus Wenger, Florent Ginhoux, Marco Prinz, Roi Avraham, Christoph Harms, Frederic Geissmann, Carsten Müller-Tidow, Stefan Uderhardt, Ivan Milenković, Liran Shlush, Steffen Jung, Aditee Kadam, Sylwia Piatek, Laura Kate Ismajli, Philipp Böhm-Sturm
| Cell Reports Verified
Keywords microglia monocytes brain macrophages HSC DNMT3A R882H clonal hematopoiesis ARCH CH CHIP Research topic(s) CP: Immunology CP: Neuroscience Introduction Microglia (Mg) are critical players in central nervous system (CNS) development, homeostasis, and immune defense.1 They originate from primitive macrophage (MΦ) progenitors that arise in the yolk sac (YS), infiltrate the developing brain, and clonally expand.2,3,4,5 YS-derived Mg (YSMg) persist throughout adulthood, displaying...
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