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Aditya Bardia

As seen in: Nature, The Oncologist, MDPI, JAMA (The Journal of the American Medical Association), Medscape, The Lancet, HemOnc Today, NewsBreak, AACR Journal, Cancer Discovery and
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Articles

Identifying the window of aggressive postpartum breast cancer based on the 21-gene Oncotype DX® test in women with HR+, HER2-negative breast cancer

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By Shiliang Zhang, Katelyn J. Queen, Niharika Duggirala, ERIC YANG, Marla Lipsyc-Sharf, Jennifer Shaw Racz, John Bennett, Yashila Suresh, Charlotte Hamilton, Nicole Chien, Emily La, Christy A. Russell, Aditya Bardia, Nimmi S Kapoor, Kaden Hong, Meghana Pitta
| Nature Verified
Abstract Postpartum breast cancer (PPBC) is associated with worse outcomes in young women with breast cancer and demonstrates distinct transcriptomic features, yet a temporal definition based on gene expression has not been established. We conducted a single-institution retrospective cohort study to evaluate the impact of postpartum status on the 21-gene Oncotype DX Recurrence Score® (RS) in hormone receptor-positive, HER2-negative young women with breast cancer.
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Activating a B cell immune response regresses immunologically cold tumours

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By Heena Aggarwal, Nimish Gupta, Arindam Sarkar, Ivan S. Pires, Tanmoy Saha, Binayak Sarkar, Ashish Kulkarni, Vinay S. Mahajan, Lipika Goyal, Aditya Bardia, Richard Fahrner, Raghunath Ananth Mashelkar, Patrick Soon-Shiong, Hae Lin Jang, Shiladitya Sengupta, Aniruddha Sengupta, Sanghamitra Mylavarapu, Ermanno Gherardi
| Nature Verified
Abstract Progress in immuno-oncology has been stymied by poorly immunogenic ‘cold’ tumours and the focus on T cells at the cost of other immune cells. Here we report that AT-1965, a small molecule in a lipid nanoparticle, induces rapid regression of poorly immunogenic tumours with the formation of immune memory through interaction with Cap-specific RNA (nucleoside-2′-O-)-methyltransferase 2 (CMTR2) in cancer cells, triggering an innate inflammatory viral defence response.
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Exercise Oncology: Beyond Weight Management in Cancer Care

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By Jennifer A. Ligibel, Javier Cortés, Aditya Bardia
| ONCOLOGY journal Verified
While exercise is often viewed through the lens of weight management, its benefits in the oncology setting extend far deeper than the number on a scale. In exercise oncology, physical activity is increasingly recognized as a potent, independent intervention that can fundamentally alter cancer outcomes. Jennifer A. Ligibel, MD, discussed the enormous value of exercise as a tool for both prevention and survival.
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