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Adrian Baris

As seen in: Nature, BioRxiv
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Articles

Hepatic stellate cell activation in the postpartum liver is consistent with pre-metastatic niche establishment

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By Michelle Ozaki, Canping Chen, Sarah M. Bernhardt, Adrian Baris, Hannah Erickson, Naoki Oshimori, Zheng Xia, Pepper Schedin, Hatun Duran Cete, Ruthanne Zareyna, Melody Brizuela
| Nature Verified
Abstract Postpartum breast cancer (PPBC), diagnosed within 10 years of the last childbirth, has an increased risk of liver metastasis. In murine models, tumor transplant studies reveal that weaning-induced liver involution is a key determinant of breast cancer metastasis to the liver. Here we explored potential mechanisms by which hepatic stellate cells (HSCs), the tissue-resident liver fibroblasts, contribute to pre-metastatic niche formation immediately following weaning.
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Enhancement of Therapeutic Transgene Insertion for Murine Phenylketonuria

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By Michael Martinez, Adrian Baris, Daelyn Y Richards, Shelley R Winn
| BioRxiv
Abstract Low in vivo transgene integration frequency limits the therapeutic efficacy of homology-directed repair (HDR)-mediated gene insertion as a treatment for Mendelian disorders. This study demonstrates improved efficacy of HDR-mediated gene insertion for the treatment of murine phenylalanine hydroxylase (PAH) deficiency, a model of human phenylketonuria (PKU), through pharmacologic inhibition of competing DNA repair pathways.
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Tumor cell intrinsic RIG-I activation co-opts the host microenvironment to drive immune mediated tumor rejection

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By Eugenia Fraile-Bethencourt, Sokchea Khou, Adrian Baris, Rebecca Ruhl
| BioRxiv
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