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Ruthanne Zareyna on Muck Rack

Ruthanne Zareyna

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Articles

Hepatic stellate cell activation in the postpartum liver is consistent with pre-metastatic niche establishment

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By Michelle Ozaki, Canping Chen, Sarah M. Bernhardt, Adrian Baris, Hannah Erickson, Naoki Oshimori, Zheng Xia, Pepper Schedin, Hatun Duran Cete, Ruthanne Zareyna, Melody Brizuela
| Nature Verified
Abstract Postpartum breast cancer (PPBC), diagnosed within 10 years of the last childbirth, has an increased risk of liver metastasis. In murine models, tumor transplant studies reveal that weaning-induced liver involution is a key determinant of breast cancer metastasis to the liver. Here we explored potential mechanisms by which hepatic stellate cells (HSCs), the tissue-resident liver fibroblasts, contribute to pre-metastatic niche formation immediately following weaning.
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