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Adrian D. Hobson on Muck Rack

Adrian D. Hobson

Shrewsbury
As seen in: ACS Publications, Science Magazine, Royal Society of Chemistry
Senior Research Fellow working on Antibody Drug Conjugates (iADC & oADC) at the Abbvie Bioresearch Center, Worcester MA
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Articles

Impact of Drug-Linker on Method Selection for Analytical Characterization and Purification of Antibody-Drug Conjugates

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By Adrian D. Hobson, Lu Wang, Kan Wu, Ling C Santora
| Royal Society of Chemistry Verified
Impact of Drug-Linker on Method Selection for Analytical Characterization and Purification of Antibody-Drug Conjugates In addition to traditional characterization methods of hydrophobic interaction (HIC) and reverse phase (RP) chromatography, an anion exchange chromatography (AIEX) was developed to analyze and purify antibody drug conjugates (ADCs).
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An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases

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By Emmeran Le Moal, Michael McPherson, Jianxing Yin, Adrian D. Hobson
| Science Magazine Verified
Research Article INFLAMMATORY DISEASES Michael J. McPherson https://orcid.org/0000-0001-6344-4600 michael.mcpherson@abbvie.com, Adrian D. Hobson https://orcid.org/0000-0003-3948-0577, [...] , Axel Hernandez Jr., Christopher C. Marvin https://orcid.org/0000-0003-4984-8435, [...] , Wendy Waegell, Christian Goess https://orcid.org/0000-0002-5873-9305, Jason Z. Oh https://orcid.org/0000-0001-5302-5971, Dan Shi https://orcid.org/0000-0001-5658-4314, Martin E.
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An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases

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By Emmeran Le Moal, Michael McPherson, Jianxing Yin, Adrian D. Hobson
| Science Magazine Verified
Acknowledgments This paper is dedicated to the memory of our colleague Wendy Waegell. We thank AbbVie employees M. Wolke for GRM-1 payload identification, E. Dominguez for MesoScale Discovery support, and Russell Judge for x-ray crystallography support; AbbVie Comparative Medicine East for preclinical in vivo support; AbbVie Bioresearch Center Histology Lab for technical support; AbbVie employees J. Maull, C. Szynal, T. Yes, Y. Kim, B. Cui, and A. McGuire and former AbbVie employees B. Bettencourt, S.
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