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IL-1 receptor antagonist-deficient (IL-1rn−/−) mice develop spontaneous polyarthritis that mimics human rheumatoid arthritis. We investigated whether a Toll-like receptor (TLR)/IL-1R signaling adaptor MyD88 and its downstream protein kinase D1 (PKD1) play a role in the development and progression of arthritis in IL-1rn−/− mice.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.