Agenor Limon

Abstract Schizophrenia (SCZ) is a complex psychiatric disorder with unclear biological mechanisms. Spectrins, cytoskeletal proteins linked to neurodevelopmental disorders, are regulated by the AKT/GSK3 pathway, which is implicated in SCZ. However, the impact of SCZ-related dysregulation of this pathway on spectrin expression and distribution remains unexplored.

Abstract Common mitochondrial DNA (mtDNA) deletions are large structural variants in the mitochondrial genome that accumulate in metabolically active tissues with age and have been investigated in various diseases. We applied the Splice-Break2 pipeline (designed for high-throughput quantification of mtDNA deletions) to human RNA-Seq datasets and describe the methodological considerations for evaluating common deletions in bulk, single-cell, and spatial transcriptomics datasets.

The Xenopus is a special study model in experimental research. In embryology, it has been used to understand the harmonious development of a complex organism from its fertilized cell. In toxicology, it is the model of choice for observing the deleterious effects of endocrine disruptors. In pharmacology, female oocytes have been used for over forty years to express genes of interest. In fact, the membrane of Xenopus oocytes is relatively poor in membrane receptors and ion channels.