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Ah Jung Heo

As seen in: Cell Press
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Articles

The Cys/N-degron pathway in the ubiquitin-proteasome system and autophagy

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By Ah Jung Heo, Chang Hoon Ji, Yong Tae Kwon
| Cell Press Verified
Crosstalk and interplay between the ubiquitin–proteasome system and autophagy. Mol. Cells. 40: 441-449 The ubiquitin system, autophagy, and regulated protein degradation. Annu. Rev. Biochem. 86: 123-128 Assembly of the 20S proteasome. Biochim. Biophys. Acta. 1843: 2-12 Autophagy in major human diseases. EMBO J. 40e108863 N-degron and C-degron pathways of protein degradation. Proc. Natl. Acad. Sci. U. S. A. 116: 358-366 In vivo half-life of a protein is a function of its amino-terminal residue. Science.
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The N-Degron Pathway Mediates ER-phagy

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By Hee Yeon Kim, Su Hyun Lee, Chang Hoon Ji, Ah Jung Heo
| Cell Press Verified
Highlights • The autophagic adaptor p62 mediates autophagic degradation of the ER (ER-phagy) • The ER membrane E3 ligase TRIM13 is a ubiquitin-dependent ER-phagy receptor to p62 • N-terminal arginylation is an ER-phagy degron via binding to the ZZ domain of p62 • p62-TRIM13-Nt-Arg circuit mediates ER protein quality control and homeostasis Summary The endoplasmic reticulum (ER) is susceptible to wear-and-tear and proteotoxic stress, necessitating its turnover.
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