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Ahmad Hamza Elsabbagh on Muck Rack

Ahmad Hamza Elsabbagh

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Articles

ERα activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness

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By Janni Yuval, Xintao Li, Juha Aalto, Ruoci Hu, Jooman Park, Yanyu Qian, Shaolei Xiong, Aditya Chhikara, Zuoxiao Shi, Lifeng Liu, Yanhui Li, Zhenyuan Song, Abeer M. Mahmoud, Jiwang Chen, Joseph A. Baur, Yanlin He, Brian T. Layden, Zhenqi Zhou, Pingwen Xu, Ahmad Hamza Elsabbagh, Huailing Fan
| Science Magazine Verified
Abstract Beige adipocytes are inducible thermogenic fat cells that emerge within white adipose tissue (WAT) in response to thermogenic stimuli and confer metabolic benefits. However, obesity impairs the generation of beige adipocytes, and the underlying mechanisms remain poorly understood. Here, we show that obesity leads to a loss of adipose progenitor cells (APCs) in WAT, accompanied by reduced estrogen (E2) levels and nicotinamide phosphoribosyltransferase (NAMPT) expression.
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