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Development of pH-responsive gelatin/PVP nanogel by gamma radiation for controlled delivery of silibinin
Abstract Silibinin (SB) is a natural polyphenolic flavonoid with recognized health and therapeutic potential. SB has poor aqueous solubility, which limits its bioavailability and therapeutic effectiveness. To overcome these limitations, a pH-responsive gelatin/polyvinylpyrrolidone (Gel/PVP) nanogel was synthesized via γ-irradiation (5 kGy) for controlled SB delivery.
Correlation Between Coronary Artery Disease Severity Detected by CT Coronary Angiography and Grade of Left Ventricular Diastolic Dysfunction Detected by Echocardiography
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