Ahmed Mourad on Muck Rack

Ahmed Mourad

As seen in: The Startup, Wiley Online Library, Science Magazine, Mayo Clinic Proceedings, Canadian Family Physician, The Journal of Rheumatology, JAAD Case Reports

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Articles

Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance

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By Janni Yuval, Xintao Li, Juha Aalto, Amar Singh, Adam Herman, Shilpi Singh, Anna Tran, Anna Trần, Anders W. Matson, Ahmed Mourad, Parthasarathy Rangarajan, Naoya Sato, Joseph Rao, Gatikrushna Singh, Melanie Graham, Devanjan Dey, Samuel Menge, Ravi Masuria, Sarah Vadnais, Sabarinathan Ramachandra
| Science Magazine Verified
Abstract Inducing stable tolerance to transplants remains a challenge in immunology. Previously, we induced tolerance to allogeneic islets in nonhuman primates by preemptive alloantigen delivery to antigen-presenting cells in situ. Here, mass cytometry phenotyping with incorporated donor-derived MHC-I peptide–loaded MHC-II tetramers revealed accumulation of allospecific CD4+ T cell clusters in the spleen of tolerant recipients.
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PD‐1/PD‐L1 Checkpoint Dysfunction in Vitiligo: Novel Pathogenic Insights and Therapeutic Innovation

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By Heba Ahmed, Hanan R. Nada, Ahmed Mourad, Laila A. Rashed
| Wiley Online Library Verified
Clinical evidence from cancer immunotherapy demonstrates that the PD-1/PD-L1 pathway is essential for immune tolerance to melanocytes, with checkpoint inhibitor therapy causing vitiligo-like depigmentation in up to 25% of melanoma patients. Vitiligo pathogenesis involves interconnected checkpoint failures including elevated PD-1 expression on T cells, deficient PD-L1 expression on melanocytes, and failure of vitiligo melanocytes to upregulate PD-L1 in response to IFN-γ stimulation.
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Reduced Biofilm Accumulation on Implants Treated With Implantoplasty-An In Situ Trial With a Within‐Subject Comparison

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By Kristina Bertl, Ahmed Mourad, Magdalena Mayol, Evaggelia Papia
| Wiley Online Library Verified
1 Introduction The treatment of dental implants affected by peri-implantitis poses a clinical challenge, as in more than half of the cases, surgery is needed (Ramanauskaite, Fretwurst, and Schwarz 2021; Herrera et al. 2023).
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