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Sabarinathan Ramachandra on Muck Rack

Sabarinathan Ramachandra

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Articles

Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance

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By Janni Yuval, Xintao Li, Juha Aalto, Amar Singh, Adam Herman, Shilpi Singh, Anna Tran, Anna Trần, Anders W. Matson, Ahmed Mourad, Parthasarathy Rangarajan, Naoya Sato, Joseph Rao, Gatikrushna Singh, Melanie Graham, Devanjan Dey, Samuel Menge, Ravi Masuria, Sarah Vadnais, Sabarinathan Ramachandra
| Science Magazine Verified
Abstract Inducing stable tolerance to transplants remains a challenge in immunology. Previously, we induced tolerance to allogeneic islets in nonhuman primates by preemptive alloantigen delivery to antigen-presenting cells in situ. Here, mass cytometry phenotyping with incorporated donor-derived MHC-I peptide–loaded MHC-II tetramers revealed accumulation of allospecific CD4+ T cell clusters in the spleen of tolerant recipients.
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