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Aimo Kannt

As seen in: Nature, Wiley, MDPI, Cell Chemical Biology
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Articles

Glycan-based biological degraders targeting the cytokine immune axis

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By Michelle Seifert, Andreas Ernst Verified, Samaneh Rasoulinejad, Sarah Koellner, Ann-Kathrin Schneider, Marcin Luzarowski, Di Wu, Aimo Kannt, Schara Safarian, Tim Kollenkirchen, Nicole Lübbehusen
| Nature Verified
Abstract Targeted degradation of extracellular proteins via endo-lysosomal pathways constitutes a promising therapeutic strategy by enabling irreversible target removal and potentially reducing systemic effects of antigen accumulation. In this study, we present a systematic approach for the design and evaluation of Biological Degraders (BioDegs) that leverage receptor-mediated uptake through triantennary N-acetylgalactosamine (TGN) induced activation of the asialoglycoprotein receptor (ASGPR).
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An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD) - Nature Metabolism

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By Michele Vacca, Fiona Oakley, Christian Trautwein, Detlef Schuppan, Aimo Kannt, Olivier Govaere, Michael Allison, Yong Kim, Anna Lindblom, Franklin J. Schlerman, Marta B. Afonso, Scott Friedman Verified, Shuang Wang, Eric Simon, Ioanna Maria Grypari, Hiroaki Yashiro, Maja Andersen, Carla Yunis, Sara Wells, Jörn M. Schattenberg, Quentin M Anstee, Dina Tiniakos, Evangelia Petsalaki, Ioannis Kamzolas, Lea Mørch Harder, Barbara Bernardo, Iwona Ksiazek, Michael Feigh, James W. Perfield, Peter Davidsen
| Nature Verified
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, encompasses steatosis and metabolic dysfunction-associated steatohepatitis (MASH), leading to cirrhosis and hepatocellular carcinoma. Preclinical MASLD research is mainly performed in rodents; however, the model that best recapitulates human disease is yet to be defined.
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Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation

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By Aimo Kannt, Fraunhofer Cluster, Pharmacology ITMP
| Cell Chemical Biology Verified
Abed D.A. Goldstein M. Albanyan H. Jin H. Hu L. Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents. Acta Pharm. Sin B. 2015; 5: 285-299 Arvinas, Inc. ARV-471 and ARV-110 program updates, 14th December 2020. Banik S.M. Pedram K. Wisnovsky S. Ahn G. Riley N.M. Bertozzi C.R. Lysosome-targeting chimaeras for degradation of extracellular proteins. Nature. 2020; 584: 291-297 Boike L. Cioffi A.G. Majewski F.C. Co J. Henning N.J. Jones M.D. Liu G.
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