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A.J. Barr

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Design and synthesis of novel benzoic acid derivatives as striatal-enriched protein tyrosine phosphatase (STEP) inhibitors with neuroprotective properties

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By Y. Nishizawa, N.K. Tonks, A.J. Barr
| ScienceDirect Verified
As a major posttranslational modification, reversible protein tyrosine phosphorylation is adjusted precisely by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) [1], [2], [3]. Proper levels of protein tyrosine phosphorylation are important for virtually all aspects of cellular functions [4], [5], [6], [7], [8].
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