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michael davies

New York
As seen in: Color Research & Application, Nature, Bandcamp Daily, ZDNet, JAMA (The Journal of the American Medical Association), JAMA: Journal of the American Medical Association, The Lancet, WhatsOnStage, CustomerThink, ITWeb and

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Articles

Personalized targeting of BCL2 family proteins overcomes acquired resistance to BRAF-MEK inhibitors in preclinical melanoma

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By Debora A. Ledesma, Courtney W Hudgens, Diana Shamsutdinova, Mehboob Ali, Zhenlin Ju, Min Xiao, Toshitha Kannan, Gregory Fontenot, Michael Nakazawa, Khalida Wani, Clifford Stephan, Phyu P Aung, Lawrence N. Kwong, Janos Roszik, Rehan Akbani, Andrew V. Kossenkov, Vito W. Rebecca, Ryan Sullivan, Meenhard Herlyn, michael davies, Y.N. Vashisht Gopal, Evelyn de Groot, Kaley Loftin, Barbara Knighton, Monzy Thomas
| Nature Verified
Abstract There are currently no effective targeted therapies for BRAF-mutant metastatic melanoma patients with acquired resistance to approved BRAF and MEK inhibitors (BRAFi and MEKi), and very few ongoing clinical trials. Anti-apoptotic BCL2 family proteins promote de novo resistance to several therapies, including single-agent BRAFi in BRAF-mutant melanomas.
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Nell Gwynn at Shakespeare North Playhouse – review

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By michael davies
| WhatsOnStage Verified
Rose Shalloo in Nell Gwynn, © Pamela Raith She’s better known these days as the playwright responsible for giving Paddington Bear his big break on a West End stage, but almost a decade ago, Jessica Swale was premiering her rumbustious life story of the famous Restoration orange-seller-turned-actress Nell Gwynn. And it feels as if the passion she expressed then for putting unheard voices centre stage is more necessary than ever.
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The Tempest with Kenneth Branagh at the RSC – review

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By michael davies
| WhatsOnStage Verified
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