Alan Moses
As seen in:
Nature,
The Guardian,
WebMD,
Yahoo News,
Yahoo News UK,
PLOS,
The London Standard,
Chicago Tribune,
Yahoo Sports Canada,
Science Magazine
and
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Alan Moses
Sir Colin Mackay obituary
When he was a barrister Colin Mackay had the courage to pursue difficult cases, including that of the boxer Michael WatsonPhotograph: none If you wanted to identify the ideal judge you just had to watch and listen to my friend Colin Mackay, a high court judge between 2001 and 2013, who has died aged 82. His authority was cloaked in unassuming sympathy. He had no need to trumpet his undoubted intellect or forensic skills.
Why axe so many juries? My plan would solve the courts crisis without harming justice
Solicitors and legal academics protest outside Westminster Abbey against the government’s plans to restrict trial by jury, 10 March 2026. Photograph: James Manning/PA Hyperbolic cliches fly back and forth in the debate about the abolition of jury trials. The dispute will never be resolved and it distracts from the problem facing us today: how to reduce the current disastrous backlog of cases? The controversy is not new.
Motifs and chemistry dictate the role of intrinsically disordered regions - Nature Cell Biology
Research shows that the function of intrinsically disordered regions within proteins relies on both linear sequence motifs and broader chemical context, allowing evolution to preserve function without strict sequence conservation. Motifs and contextual chemistry jointly determine activity, with chemistry able to compensate for a loss of motifs.
Disorder meets its match
Abstract Most proteins encoded in the human genome work in groups to carry out specific functions (1). For example, mitochondrial complex I, which is responsible for the cell’s energy production, has a defined number of subunits that are largely bound by stable interactions (2). By contrast, certain tasks such as cellular information processing (or “signaling”) require dynamic interactions. Proteins bind to each other only briefly to transmit information, then separate.
Unsupervised Whole-Genome Representation Learning Captures Bacterial Phenotypes
Abstract Shifting from hand-crafted to learned representations of data has revolutionized fields like natural language processing and computer vision. Despite this, current approaches to bacterial phenotype prediction from the genome rely on training machine learning models on hand-crafted features, often binary indicators or counts of the presence of different conserved genomic elements and protein domains.
Inferring fungal cis-regulatory networks from genome sequences
Abstract Gene expression patterns are determined to a large extent by transcription factor binding to non-coding regulatory regions in the genome. However, gene expression cannot yet be systematically predicted from genome sequences, in part because non-functional matches to the sequence patterns (motifs) recognized by transcription factors (TFs) occur frequently throughout the genome.
Improving the performance of supervised deep learning for regulatory genomics using phylogenetic augmentation
Abstract Motivation Supervised deep learning is used to model the complex relationship between genomic sequence and regulatory function. Understanding how these models make predictions can provide biological insight into regulatory functions. Given the complexity of the sequence to regulatory function mapping (the cis-regulatory code), it has been suggested that the genome contains insufficient sequence variation to train models with suitable complexity.
Improving the performance of supervised deep learning for regulatory genomics using phylogenetic augmentation
Abstract Motivation: Supervised deep learning is used to model the complex relationship between genomic sequence and regulatory function. Understanding how these models make predictions can provide biological insight into regulatory functions. Given the complexity of the sequence to regulatory function mapping (the cis-regulatory code), it has been suggested that the genome contains insufficient sequence variation to train models with suitable complexity.
Study: No higher risk for esophageal cancer in people with reflux
Rebutting conventional wisdom, a large Swedish study finds that most people with chronic acid reflux, or GERD, do not have a higher risk for developing cancer of the esophagus. "Previous studies have shown that individuals with repeated symptoms of acid reflux - [such as] heartburn and/or regurgitation -- have a propensity to develop esophageal cancer," said lead researcher Dr. Dag Holmberg, a postdoctoral researcher at the Karolinska Institute in Stockholm.
Functional similarity of non-coding regions is revealed in phylogenetic average motif score representations
New Results doi: https://doi.org/10.1101/2023.04.09.536185 Abstract Here we frame the cis-regulatory code (that connects the regulatory functions of non-coding regions, such as promoters and UTRs, to their DNA sequences) as a representation building problem. Representation learning has emerged as a new approach to understand function of DNA and proteins, by projecting sequences into high-dimensional feature spaces, where the features are learned from data by a neural network.
Architect: A tool for aiding the reconstruction of high-quality metabolic models through improved enzyme annotation
Abstract Constraint-based modeling is a powerful framework for studying cellular metabolism, with applications ranging from predicting growth rates and optimizing production of high value metabolites to identifying enzymes in pathogens that may be targeted for therapeutic interventions. Results from modeling experiments can be affected at least in part by the quality of the metabolic models used.
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
Abstract Deep learning-based approaches to protein structure prediction, such as AlphaFold2 and RoseTTAFold, can now define many protein structures with atomic-level accuracy. The AlphaFold Protein Structure Database (AFDB) contains a predicted structure for nearly every protein in the human proteome, including proteins that have intrinsically disordered regions (IDRs), which do not adopt a stable structure and rapidly interconvert between conformations.
Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations
Summary It is unclear how disease mutations impact intrinsically disordered protein regions (IDRs), which lack a stable folded structure. These mutations, while prevalent in disease, are frequently neglected or annotated as variants of unknown significance. Biomolecular phase separation, a physical process often mediated by IDRs, has increasingly appreciated roles in cellular organization and regulation.
Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis
) to introduce a cytosolic red fluorescent protein (RFP), a marker of cell boundaries, into the ORF-GFP array (a list of all strains assayed is shown in ) ( Our goal was to create an automated platform to quantify the abundance and localization of the ∼4,100 visible fusion proteins in the ORF-GFP collection.
HPV Shot Rids 97-Year-Old of Advanced Skin Cancer
By Alan Moses HealthDay Reporter TUESDAY, July 17, 2018 (HealthDay News) -- Two years ago, Ian McKenzie thought his mom's remaining days were dwindling. The 97-year-old woman had developed a severe case of what was thought to be an untreatable form of squamous cell carcinoma, the second leading form of skin cancer. Lesions had developed over much of her right leg, in such numbers and size that chemotherapy and surgery were ruled out as treatments.
By 2045, nearly one-quarter of world’s population will have obesity
The prevalence of obesity worldwide will reach nearly 25% by 2045, further increasing the burden of diabetes and putting an even greater strain on global health systems, according to an analysis of population data presented at the European Congress on Obesity annual meeting. “While the diabetes epidemic is driven by many factors, including age and genetics, there are modifiable factors that play a huge role, of which the major one is obesity,” Alan C.
Sir Alan Moses, chairman, Independent Press Standards Association: Sack Trevor Kavanagh from the board of IPSO
On August 14 the Sun published a hate?filled and bigoted oped by Trevor Kavanagh. Kavanagh described Muslims as "a specific rather than a cultural problem". He concluded the piece with the question: "What will we do about The Muslim Problem then?" The phrase, "The Muslim Problem", was printed with capitalisation and italics. It resembles the notorious phrase used by the Nazis in the 1930s, "The Jewish Problem".
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Alan
Contact Alan, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack