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Articles by Alan Rolfe
HMRC introduces targeted advance assurance service for R&D claims
From 18 May 2026 onwards, HMRC will now have two types of advance assurance for R&D claims.
Directors loan accounts – Avoid the unexpected tax trap
Company owners often withdraw monies from their business that is not salary or dividends, this borrowing can be useful but if it is not managed properly tax charges will arise. This tax charge is levied on a close company when a participator (or their associate) in a close company withdraws funds from their company which total over £15,000. For loans taken out from 6 April 2026 the rate of tax charged was 35.75% and before this the loan would be charged at 33.75%.
Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket
Highlights • A high-throughput screen identifies a small-molecule inhibitor of CPS1, H3B-120 • H3B-120 binds to an allosteric pocket to achieve highly selective inhibition of CPS1 • Analogs of H3B-120 block CPS1 cellular activity in primary human hepatocytes Summary Carbamoyl phosphate synthetase 1 (CPS1) catalyzes the first step in the ammonia-detoxifying urea cycle, converting ammonia to carbamoyl phosphate under physiologic conditions.
The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity
Tuong-Vi Nguyen‡, Shihua Yao‡, Yahong Wang§, Alan Rolfe‡, Anand Selvaraj‡, Rachel Darman‡, Jiyuan Ke‡, Markus Warmuth‡, Peter G. Smith‡, Nicholas A. Larsen‡, Lihua Yu‡, Ping Zhu‡, Peter Fekkes‡, Frédéric H. Vaillancourt‡ and David M. Bolduc‡1 ‡H3 Biomedicine Inc., Cambridge, Massachusetts 02139 §ChemPartner Co., Ltd., 998 Halei Road, Shanghai 201203, China ↵1 To whom correspondence should be addressed: H3 Biomedicine Inc., 300 Technology Square, Cambridge, MA 02139.
The R882H DNMT3A hotspot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity
Author contributions: T.-V.N., S.Y., Y.W., R.D., J.K., and D.M.B. data curation; T.-V.N., S.Y., Y.W., A.R., A.S., R.D., J.K., M.W., P.G.S., N.A.L., P.Z., P.F., F.H.V., and D.M.B. formal analysis; T.-V.N., A.R., A.S., R.D., M.W., P.G.S., N.A.L., P.Z., P.F., F.H.V., and D.M.B. investigation; T.-V.N., N.A.L., F.H.V., and D.M.B. writing-original draft; T.-V.N., N.A.L., F.H.V., and D.M.B. writing-review and editing; A.R., M.W., P.G.S., P.Z., P.F., F.H.V., and D.M.B. project administration; M.W.,...
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