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Articles by Alan Sinclair
The importance of identifying a frailty metabolic phenotype in managing frail older people with type 2 diabetes
International Diabetes Federation. IDF Diabetes Atlas, 11th edition. Brussels, Belgium: International Diabetes Federation, 2025. Accessed 1st April 2026. Sinclair AJ, Abdelhafiz AH, Rodríguez-Mañas L. Frailty and sarcopenia - newly emerging and high impact complications of diabetes. J Diabetes Complications 2017;31:1465-1473. https://doi.org/10.1016/j.jdiacomp.2017.05.003 Gregg EW, Mangione CM, Cauley JA, et al for the Study of Osteoporotic Fractures Research Group.
The Effect of Frailty on Body Composition and Its Impact on the Use of SGLT-2 Inhibitors and GLP-1RA in Older People with Diabetes
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Meeting clean energy ambitions will require a fundamental rethink around delivery
Earlier this month the National Energy System Operator (NESO) took a seemingly radical decision to pause new entrants to the long queue for connection to Britain’s grid. In response to overwhelming demand, Neso has made the move to allow it to reform the planning process for connections. However the challenge is not just around connectivity, but also delivery more widely.
The Use of SGLT-2 Inhibitors and GLP-1RA in Frail Older People with Diabetes: A Personalised Approach Is Required
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'Accelerating energy infrastructure: the importance of policy, and confidence in delivery' by Alan Sinclair
After a period of extended economic and political uncertainty, the UK must urgently accelerate expansion and renewal of its energy infrastructure to meet decarbonisation deadlines and enable key growth areas like data centres and advanced manufacturing. Proactive and consistent policymaking is essential; however, to drive investment, confidence in delivery must be built.
If the UK wants nuclear innovation, it must create an environment for it to succeed
Few topics produce the same frisson of excitement from those in energy sector as nuclear power. Nottingham’s new prototype nuclear fusion plant. Small modular reactors (SMRs). The next generation of nuclear fission power plants – with Hinkley Point C in construction and Sizewell C preparing for a final investment decision. The UK is at the centre of nuclear innovation – or at least it should be.
Impact of deintensifying hypoglycaemic drugs in older adults with type 2 diabetes: protocol for an emulation of a target trial
Diabetes and endocrinology Impact of deintensifying hypoglycaemic drugs in older adults with type 2 diabetes: protocol for an emulation of a target trial Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Comment on: Data‐driven classification of health status of older adults with diabetes: The diabetes and aging study
Abstract See the Reply by Elbert et al. To the Editor: We have read with great interest the recent article of Prof. Elbert Huang and colleagues1: “Data-driven classification of health status of older adults with diabetes: The diabetes and aging study”. The authors aimed to classify a cohort of 105,786 older adults with type 2 diabetes based (the Kaiser Permanente Northern California Diabetes Registry) on the patients' comorbidities.
Metabolic Characteristics of Frail Older People with Diabetes Mellitus—A Systematic Search for Phenotypes
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Metabolic Impact of Frailty Changes Diabetes Trajectory
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Alan J. Sinclair 1,2 and Ahmed H. Abdelhafiz 1,3,* 1 Foundation for Diabetes Research in Older People (fDROP), Buckinghamshire SL6 0JB, UK 2 King’s College, London WC2R 2LS, UK 3 Department of Geriatric Medicine Rotherham General Hospital, Rotherham S60 2UD, UK * Author to whom correspondence should be addressed.
Care home diabetes: an important part of community diabetology where high standards of diabetes care are essential
Role of the National Advisory Panel on Care Home Diabetes (NAPCHD) Authors Professor Alan Sinclair fDROP and King's College, London Dr Ahmed H.
Challenges and Strategies for Diabetes Management in Community‐Living Older Adults
From Research to Practice Abstract The prevalence of diabetes is increasing, especially in older people, mainly because of an increase in life expectancy. The number of comorbidities also increases with increasing age, leading to a unique diabetes phenotype in old age that includes vascular disease, physical and neuropathic complications, and mental dysfunction.
The Truth about Drug Abuse in White Collar Professions in Australia
When thinking of a drug addict, most people picture someone lowly educated and living off crime. However, in Australia, the profile of a drug abuser challenges these stereotypes. In our country, drug abuse is a problem not exclusive to unemployed or low skilled workers. In fact, there is one sector that is contributing to Australia’s steadily growing drug problem — the white collar professionals. The typical drug user in Australia is a professional with tertiary education.
Cognitive Dysfunction in Older Adults with Type 2 Diabetes
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 The pathogenic link between diabetes mellitus and cognitive dysfunction. AGE, advanced glycation end products; BBB, blood-brain barrier; DM, diabetes mellitus. The prevalence of comorbid diabetes and cognitive dysfunction increases as the population ages.
Type 2 diabetes and cognitive dysfunction-towards effective management of both comorbidities
1. Sinclair AJ Girling AJ Bayer AJ Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services. All Wales Research into Elderly (AWARE) study. Diabetes Res Clin Pract. 2000; 50: 203-212 2. Saeedi P Petersohn I Salpea P et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas. Diabetes Res Clin Pract. 2019; 157 ()107843 3.
Evaluating glucose‐lowering treatment in older people with diabetes: Lessons from the IMPERIUM trial
Abstract Understanding the benefits and risks of treatments to be used by older individuals (≥65 years old) is critical for informed therapeutic decisions. Glucose‐lowering therapy for older patients with diabetes should be tailored to suit their clinical condition, comorbidities and impaired functional status, including varying degrees of frailty.
Evaluating glucose‐lowering treatment in older people with diabetes: Lessons from the IMPERIUM trial
REVIEW ARTICLE Jacek Kiljański MD Corresponding Author E-mail address: kiljanski_jacek@lilly.com Eli Lilly and Company, Warsaw, Poland Correspondence Jacek Kiljański, Eli Lilly and Company, Eli Lilly Polska Sp. z o. o. ul. Żwirki i Wigury 18a, 02‐092 Warsaw, Poland, Email: kiljanski_jacek@lilly.com Search for more papers by this author PDF PDF ShareShare The full text of this article hosted at iucr.org is unavailable due to technical difficulties.
Diabetes and global ageing among 65-99-year-old adults: findings from the International Diabetes Federation Diabetes Atlas, 9th edition
Highlights • Globally, 1 in 5 people aged 65-99 years live with diabetes (136 million). • In 2019, the IDF North America and Caribbean Region has the highest prevalence (27.0%) in adults aged 65-99 years and Africa has the lowest (8.4%). • China, the United States of America, and India have the highest number of adults with diabetes who are older than 65 years.
Mean HbA1c, HbA1c variability, and mortality in people with diabetes aged 70 years and older: a retrospective cohort study
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies
Managing glycaemia in older people with type 2 diabetes: a retrospective, primary care based cohort study, with economic assessment of patient outcomes - Gordon - 2016 - Diabetes, Obesity and Metabolism - Wiley Online Library
To describe the relative health and economic outcomes associated with different therapeutic approaches to managing older patients with type 2 diabetes failing metformin (M) monotherapy and escalated to second-line treatment.
Recommendations on Physical Activity and Exercise for Older Adults Living in Long-Term Care Facilities: A Taskforce Report
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