Albert Kwok Hung

Keywords computational protein design insulin insulin receptor receptor tyrosine kinase signaling trafficking metabolism diabetes severe insulin-resistance syndromes cancer Introduction The insulin receptor (IR) is a receptor tyrosine kinase (RTK) that plays an important role in metabolism, development, growth, and proliferation.1,2,3,4 The insulin-activated IR undergoes trans-autophosphorylation and phosphorylates a number of intracellular substrates, activating two major signaling...

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