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Albert R Bargoud on Muck Rack

Albert R Bargoud

As seen in: Cell Reports
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Articles

GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension

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By Jacob Sterling, Albert R Bargoud, Modupe O. Adetunji, Samyuktha Guttha
| Cell Reports Verified
Highlights • Astrogliosis contributes to retinal ganglion cell death in a mouse glaucoma model • CD11b+ CD11c+ cells contribute to astrogliosis after ocular hypertension • Reduction of inflammatory cytokines protects against astrogliosis and cell death • NLY01, a GLP-1R agonist, prevents astrogliosis and retinal ganglion cell death Summary Glaucoma is the leading cause of irreversible blindness and is characterized by the death of retinal ganglion cells (RGCs).
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Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice

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By New Brunswick, Ashley P Pettit, William O Jonsson, Albert R Bargoud
| The Journal of Nutrition Verified
Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via the integrated stress response (ISR). Objective: We explored whether a Met-restricted (MR) diet activates the ISR to reduce body fat and regulate protein balance.
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