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Alejandro Mossi Albiach on Muck Rack

Alejandro Mossi Albiach

As seen in: BioRxiv, Cell Press
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Articles

Futile wound healing drives mesenchymal-like cell phenotypes in human glioblastoma

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By Alejandro Mossi Albiach, Jokubas Janusauskas, Jesper Kjaer Jacobsen, Ivana Kapustova
| BioRxiv
Abstract Glioblastoma is the deadliest brain cancer, characterized by large cellular diversity whose complexity and organizing principles are only starting to be uncovered. Both neurodevelopment-like and mesenchymal-like cell states have been described in glioblastoma, with the latter being strongly implicated in malignancy and disease progression. However, the nature of these mesenchymal-like cell states remains unresolved.
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Glioblastoma is spatially organized by neurodevelopmental programs and a glial-like wound healing response

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By Alejandro Mossi Albiach, Jokubas Janusauskas, Egle Kvedaraite, Ivana Kapustova
| BioRxiv
Abstract Glioblastoma is the deadliest brain cancer, characterized by great cellular diversity and unique histology. To understand the spatial organization of transcriptional cell states, we mapped the expression of 888 genes in centimeter-scale tissue sections from a large patient cohort. We found a hierarchy of cellular states akin to normal brain development, including proliferating and differentiated cells interacting with the stroma.
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Transcriptomic diversity of cell types across the adult human brain

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By Kimberly Siletti, Rebecca D. Hodge, Alejandro Mossi Albiach, Lijuan Hu
| BioRxiv
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