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Alessandra De Souza

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Articles

Cross-Species Hepatic Metabolism of the Antileishmanial Chalcone NAT22 Generates Metabolites with Enhanced Affinity for the Parasite Target cTXNPx

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By Ana Valente, Alessandra De Souza, Arielly R. R. Barreto
| Preprints.org
You are already at the latest version Background/Objectives: Human and canine leishmaniasis are neglected diseases with limited therapeutic options. The nitrochalcone NAT22, a high-affinity inhibitor of the essential parasite enzyme tryparedoxin peroxidase (cTXNPx), has emerged as a promising antileishmanial candidate. Interestingly, NAT22 demonstrated superior efficacy when administered orally rather than intralesionally, suggesting metabolism-driven enhancement of activity.
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Competência em informação como inovação social no sistema de justiça: ambiguidades entre teoria e prática

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By Alessandra De Souza, Marta Macedo, Luiz Cláudio Gomes, Kerr Pinheiro
| Dialnet - Universidad de La Rioja
Alessandra de Souza Santos [1] ; Luiz Cláudio Gomes Maia [1] ; Marta Macedo Kerr Pinheiro [2] [1] Universidade FUMEC, Brasil [2] Universidade Federal de Minas Gerais (UFMG), Brasil Localización: Brazilian Journal of Information Science, ISSN-e 1981-1640, Nº.
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