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Alessandro Barbarulo on Muck Rack

Alessandro Barbarulo

As seen in: Science Magazine, BioRxiv, Cell Press
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Articles

NF-κB dependent expression of A20 controls IKK repression of RIPK1 dependent cell death in activated T cells

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By Scott Layzell, Alessandro Barbarulo, Benedict Seddon
| BioRxiv
Abstract The Inhibitor of Kappa B Kinase (IKK) complex is a critical regulator of canonical NF-κB activation. More recently, RIPK1 has also been identified as a phosphorylation target of the IKK complex, resulting in repression of extrinsic cell death pathways. Our previous work shows that normal thymocyte development is exclusively reliant on repression of TNF triggered cell death pathways by IKK, and that NF-κB signalling is in fact redundant for development.
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Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

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By Louise Webb, Tom Vanden Berghe, Alessandro Barbarulo, Jelle Huysentruyt
| Cell Press Verified
Highlights • The IKK complex is essential for survival of SP thymocytes • Developmental progression of SP thymocytes does not require canonical NF-κB • Expression RIPK1 is induced in thymocytes following positive selection • Survival of SP thymocytes depends upon active repression of RIPK1 by IKK Summary NF-κB (nuclear factor κB) signaling is considered critical for single positive (SP) thymocyte development because loss of upstream activators of NF-κB, such as the IKK complex, arrests their...
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