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Alessandro Bruno

As seen in: Nature, Wiley Online Library, La Repubblica, Science Magazine, International Journal of Biomedical Imaging, International Journal of Digital Multimedia Broadcasting, Astronomy and Astrophysics (A&A), Proactive Investors, The Journal of Allergy & Clinical Immunology, Gastrointestinal Endoscopy and
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Articles

Tumor-targeted interferon-α gene therapy for glioblastoma: a phase 1 trial

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By Bernhard Gentner, Marica Eoli, Francesca Farina, Matteo Barcella, Alessia Capotondo, Antonio Francavilla, Matteo G. Carrabba, Valeria Ferla, Alessandro Bruno, Giorgia Alvisi, Eugenio Montini, Maria Grazia Bruzzone, Francesco Di Meco, Paolo Ferroli, Francesco Acerbi, Roberto Pallini, Quintino Giorgio D’Alessandris, Alessandro Olivi, Filippo Gagliardi, Silvia Snider, Pietro Mortini, Valeria Berno, Pietro Luigi Poliani, Carlo Russo, Fabio Ciceri, Luigi Naldini, Stefania Mazzoleni, Valentina Brambilla, Mariagrazia Garramone, Nadia Coltella, Leila Hadadi, Charlotte Capt, Valeria Cuccarini, Federico G. Legnani, Monica Patanè, Amleto Fiocchi, Gaetano Finocchiaro
| Nature Verified
Abstract Glioblastoma (GBM) is an immunologically cold brain tumor with poor outcome, characterized by a myeloid-driven immunosuppressive microenvironment. Here we report an interim analysis of a first-in-human phase 1/2a dose-escalation study evaluating Temferon—a genetically engineered autologous stem cell transplant designed to deliver interferon-α2 by means of myeloid progeny recruited to the GBM TME and locally activate antitumor immunity.
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Mo1665 SUSTAINED LONG-TERM IMPROVEMENT OF BOWEL URGENCY IN IBD PATIENTS TREATED WITH ADVANCED THERAPIES: A MULTICENTRE STUDY

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By Olga Maria Nardone, Alessandro Bruno, Raffaella El Khoury
| Gastrointestinal Endoscopy Verified
Also available on ScienceDirect
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The Two Facets of AI Sustainability: Better Infrastructure and More Environmental Responsibility

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By Alessandro Bruno
| Planet Mainframe
Artificial intelligence (AI) is a field of computer systems designed to simulate human thought or part of it, with the latest generation of products, such as ChatGPT, drawing from vast web content, processing responses, and training themselves to respond more effectively to user input. AI typically operates in the cloud, passing through large servers, which require energy and water consumption.
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