Highlights • Color opponency is common among neurons within a chromatic zone in the mouse LGN • Cone inputs to LGN drive color opponency across mesopic to photopic light levels • Cone inputs to opponent neurons derive from central and upper visual field • Subsets of LGN neurons display opponency for small or large stimuli only Summary Color vision, originating with opponent processing of spectrally distinct photoreceptor signals, plays important roles in animal behavior., , , Surprisingly,...