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Alexa Pichet Binette

As seen in: Nature, Wiley, Wiley Online Library, PLOS Biology, JAMA (The Journal of the American Medical Association), Science Magazine, BioRxiv, JNeurosci, medRxiv, Neurology and
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Articles

Alzheimer’s disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA

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By xiaofan LI, Ruyi Zhou, Keenan A. Walker, Cassandra O. Blew, Michael Duggan, Gabriela Gomez, Shannon M. Drouin, Jingsha Chen, Jingning Zhang, Tibor Nanasi, Benoit Lehallier, Hamilton OH, Aditya Surapaneni, Morgan E. Grams, Priya Palta, Kevin Sullivan, Alexa Pichet Binette, Lang Wu, Jingjing Zhu, Hampton Leonard, Andrew Singleton, Myriam Fornage, Cassie Joynes, Jenifer Cordon, Balint File
| Science Magazine Verified
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Mounting evidence suggests that perturbations outside the central nervous system (CNS) can modulate Alzheimer’s disease (AD).
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Proteomic signatures of the APOE ε 4 and APOE ε 2 genetic variants and Alzheimer’s disease

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By Lina Lu, Alexa Pichet Binette, Ines Hristovska, Shorena Janelidze, Bart M.N. Smets, Irene Cumplido-Mayoral, Aparna Vasanthakumar, Lijun An, Rik Ossenkoppele, Varsha Krish, Farhad Imam, Sebastian Palmqvist, Jacob Vogel, Erik Stomrud, Oskar Hansson, Niklas Mattsson-Carlgren, Britney Milkovich
| Nature Verified
Abstract The APOE locus is the strongest genetic factor for Alzheimer’s disease, with ε4 increasing and ε2 decreasing risk, yet the basis of these opposing effects remains unclear. Here we performed a multicohort proteomic analysis across plasma and cerebrospinal fluid in GNPC, BioFINDER-2, ADNI, UK BioBank, and PPMI. APOE-associated protein alterations are detectable before amyloid pathology and remain stable across age and disease progression.
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A deep joint-learning proteomics model for diagnosis of six conditions associated with dementia

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By Lijun An, Alexa Pichet Binette, Gabriele Vilkaite, Yu Xiao, Zijian Dong, Bart M.N. Smets, Rowan Saloner, Shinya Tasaki, Ying Xu, Varsha Krish, Farhad Imam, Shorena Janelidze, Danielle van Westen, Erik Stomrud, Christopher D. Whelan, Sebastian Palmqvist, Rik Ossenkoppele, Niklas Mattsson-Carlgren, Oskar Hansson, Jacob Vogel, Ines Hristovska, Romina Zendehdel
| Nature Verified
Abstract Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies.
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