Alexander Bartelt
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Fast & fuelious: the malate-aspartate shuttle in brown adipocyte lipid metabolism
AIFM2/FSP1 apoptosis-inducing factor mitochondria-associated 2 ARALAR1 aspartate–glutamate carrier 1 BAT brown adipose tissue GOT1 glutamic-oxaloacetic transaminase 1 LD lipid droplet MAS malate–aspartate shuttle NE norepinephrine NEFA non-esterified fatty acids OGC oxoglutarate carrier PKA protein kinase A UCP1 uncoupling protein 1 Non-shivering thermogenesis is the process by which brown adipose tissue (BAT) dissipates chemical energy as heat, which is linked to high oxygen consumption and...
12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
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CorrectionVolume 37, Issue 12p2470-2475 Publication History: Published online November 4, 2025 DOI: 10.1016/j.cmet.2025.10.019 External LinkAlso available on ScienceDirect External Link Copyright: © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. Main text (Cell Metabolism 30, 768–783.e1–e7; October 1, 2019) In the originally published version, some unintentional errors occurred, now corrected here.
By Luiz Osório Leiria, Chih-Hao Wang, Matthew D. Lynes, Kunyan Yang, Farnaz Shamsi, Mari Sato, Satoru Sugimoto, Emily Chen, Valerie Bussberg, Niven R. Narain, Brian E. Sansbury, Justin Darcy, Tian Huang, Sean D. Kodani, Masaji Sakaguchi, Andréa L. Rocha, Tim J. Schulz, Alexander Bartelt, Gökhan S. Hotamisligil, Michael F. Hirshman, Laurie J. Goodyear, Matthias Blüher, Aaron M. Cypess, Michael A. Kiebish, Matthew Spite, Yu-Hua Tseng, Klaus van Leyen
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Cell Metabolism
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An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis - Nature Communications
Abstract Atherosclerosis is the underlying cause of myocardial infarction and ischemic stroke. It is a lipid-triggered and cytokine/chemokine-driven arterial inflammatory condition. We identify D-dopachrome tautomerase/macrophage migration-inhibitory factor-2 (MIF-2), a paralog of the cytokine MIF, as an atypical chemokine promoting both atherosclerosis and hepatic lipid accumulation.
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