Alexander D Miras on Muck Rack

Alexander D Miras

As seen in: touchENDOCRINOLOGY, Nature, Wiley Online Library, The Irish Times, Cell Press, The Lancet, Dove Medical Press
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Articles

Targeting Multiple Gut-Brain Pathways in Obesity: Rationale for Combination Pharmacotherapy

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By Alexander D Miras, Muzamil Hussain
| Wiley Online Library Verified
BMI body mass index GIP glucose-dependent insulinotropic polypeptide GLP-1 glucagon-like peptide-1 NB-ER fixed-dose, extended-release combination of naltrexone and bupropion POMC pro-opiomelanocortin 1 Introduction Obesity is a complex disease of energy dysregulation that involves metabolic, hormonal, and neural factors, referred to as the “gut-brain axis” [1, 2].
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Oxyntomodulin physiology and its therapeutic development in obesity and associated complications

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By Ming CHONG, Alexander D Miras
| Wiley Online Library Verified
In conjunction with the relentless growth of cardiometabolic diseases, obesity is now a worldwide epidemic (Lingvay et al., 2024). Bariatric surgery remains the most effective obesity treatment, largely mediated through rewiring hormonal and neural regulation (Lingvay et al., 2024). In the last decade, pharmacotherapy has been made available for the treatment by harnessing these key hormonal alterations (Melson et al., 2024).
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Metabolic adaptation following gastric bypass surgery: results from a 2-year observational study - International Journal of Obesity

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By Shu-Dong Zhang, Alexander D Miras, Heather J Spence
| Nature Verified
Abstract Metabolic adaptation is the lowering of basal metabolic rate (BMR) beyond what is predicted from changes in fat mass (FM) and fat-free mass (FFM) and may hamper weight-loss progression. It is unclear whether metabolic adaptation occurs following gastric bypass surgery (GBP) and if it persists. The aim of this study was to evaluate the reduction in BMR that is not explained by changes in body composition in patients following GBP compared to a weight-stable comparator group.
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