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Alexander D. Naydich on Muck Rack

Alexander D. Naydich

As seen in: Cell Press
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Articles by Alexander D. Naydich

Synthetic Cassettes for pH-Mediated Sensing, Counting, and Containment

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By Finn Stirling, Alexander D. Naydich, Juliet Bramante, Rachel Barocio
| Cell Press Verified
Highlights • Containment system with an escape frequency below the detection limit of 10−11 • Evolutionary stability achieved through toxin-antitoxin balancing • Pulse counter developed that responds to the falling edge of a signal • Counter will not advance unless 2 distinct signals are registered Summary As pH is fundamental to all biological processes, pH-responsive bacterial genetic circuits enable precise sensing in any environment.
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Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface

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By Shannon N. Nangle, Johannes Bues, Alexander D. Naydich, Disha Trivedi
| asm.org
Research Article | Synthetic Biology Alexander D. Naydich, Shannon N. Nangle, Johannes J. Bues, Disha Trivedi, Nabeel Nissar, Mara C. Inniss, Matthew J. Niederhuber, Jeffrey C. Way, Pamela A. Silver, David T. Riglar Thomas J. Sharpton, Editor DOI: 10.1128/mSystems.00125-19 ABSTRACT Engineering synthetic circuits into intestinal bacteria to sense, record, and respond to in vivo signals is a promising new approach for the diagnosis, treatment, and prevention of disease.
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