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Alexander Young

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Articles

Network modeling predicts how DYRK1A inhibition promotes cardiomyocyte cycling after ischemic/reperfusion injury

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By JCI Insight, Bryce C. Murillo, Alexander Young
| The Journal of Clinical Investigation
ResearchCardiologyCell biology Open Access | 10.1172/jci.insight.200429 JCI Insight. https://doi.org/10.1172/jci.insight.200429. Copyright © 2026, Murillo et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Within-family effect of ancestry on complex traits in a Mexican population

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By Siqi Wang, Jaime Berumen, Alejandra Vergara-Lope, Elizabeth Barrera, Fernando Rivas, Diego Aguilar-Ramirez, Rory Collins, Jonathan Emberson, Michael Hill Verified, Michael Goddard, Loic Yengo, Alexander Young, Jesus Alegre-Díaz, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jason Torres, Peter M. Visscher, Paulina Baca
| Nature Verified
Abstract Human populations differ in disease prevalence and phenotypes, but the extent to which differences are caused by genetic factors is unknown for most complex traits. Comparing phenotypic means across populations is confounded by environmental differences and using polygenic predictors can lead to biased inference1,2. Family-based analyses of people of genetically admixed ancestry enable estimation of ancestry effects unconfounded by ancestry–environment correlations.
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Pannexin 1 Channels Control Cardiomyocyte Metabolism and Neutrophil Recruitment During Non-Ischemic Heart Failure

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By Caitlin M. Pavelec, Alexander Young, Hannah L. Luviano, Emily E Orrell
| BioRxiv
Abstract Pannexin 1 (PANX1), a ubiquitously expressed ATP release membrane channel, has been shown to play a role in inflammation, blood pressure regulation, and myocardial infarction. However, a possible role of PANX1 in cardiomyocytes in the progression of heart failure has not yet been investigated. We generated a novel mouse line with constitutive deletion of PANX1 in cardiomyocytes (Panx1MyHC6).
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