Ali Sonay

Despite the emergence of neoadjuvant immunotherapies, the surgical removal of a primary tumour often remains the first treatment a patient with cancer will undergo. Image-guided surgery uses real-time images to allow surgeons to see the demarcation lines between a tumour and healthy tissue and decide how much of the tissue they should remove to prevent tumour regrowth.

Abstract Ferroptosis emerged as a cell death modality for drug resistant cancer cells, but there are currently no available biomarkers for imaging ferroptosis based therapies. To address this gab, we evaluated the nanodynamic changes in lipid membranes occurring during cell death to explore potential targeting opportunities to image cell death. We nano-sized gaps at late stages of ferroptosis can serve as entry points for dyes that can bind to cellular structures.

Abstract The efficacy of fluorescence-guided surgery in facilitating the real-time delineation of tumours depends on the optical contrast of tumour tissue over healthy tissue.